(BW)(WA-ROSETTA-BIOSOFTWARE)(MRK)Rosetta Biosoftware和Sage-N Research, Inc.在用于发现蛋白质组和生物标志物的信息学平台进行合作
美国商业新闻2006年4月19日西雅图和加利福尼亚州圣约瑟消息——
Rosetta Biosoftware和Sage-N Research, Inc.今天宣布将会合作在Rosetta Biosoftware的用于发现蛋白质表达分析与生物标志物的Elucidator(R)系统及Sage-N Research的Sorcerer(TM)蛋白质组综合数据设备之间建立可互操作性，从而为客户提供用于蛋白质表达研究与蛋白质识别的先进解决方案。
Rosetta Elucidator系统是一种灵活的、可伸缩的解决方案，可以用于管理和分析大量的蛋白质组数据。它内置原始数据管理功能，PeakTeller(TM)处理模块能够识别不同表达的蛋白质，并且在缩胺酸和蛋白质水平上进行分析，从而使得研究人员能够从质谱数据中生成一列候选生物标志物。Sage-N Research的Sorcerer综合数据设备是一种小型分析系统，能够使用正在申请专利的Pattern Match Accelerator(TM)硬件与系统技术来提供蛋白质识别处理能力。
Rosetta Biosoftware副总裁兼总经理Yelena Shevelenko说道：“我们非常高兴能够为我们的共同客户提供自动化与灵活性，从而大幅提高蛋白质生物标志物发现的效率。将Elucidator系统的能够识别不同表达的蛋白质的功能与Sorcerer系统的高处理能力、高精度序列查找功能结合起来，我们能够通过自动化为客户提供更高的处理能力，从而把更多的时间放在相关的科学问题上，而不是放在验证蛋白质搜索结果上面。”
Sage-N Research首席执行官兼董事会主席David Chiang对此评论道：“Sage-N Research和Rosetta Biosoftware在易于使用的高处理能力蛋白质组数据分析解决方案上持有共识。结合这两款在各自市场均占据领导地位的产品的功能，我们能够为科学家们提供基于蛋白质组数据分析的功能强大的综合性MS-MS平台。”
Sorcerer和Elucidator系统的共同客户能够立即享受到两款产品结合所带来的收益。Sage-N Research和Rosetta Biosoftware打算合作为其共同解决方案提供客户支持。
关于Sorcerer综合数据设备
Sorcerer综合数据设备(IDA)是一款能够在几分钟内就设置完毕的小型分析系统，其不需要任何软件安装以及信息技术管理。采用正在申请专利的Pattern Match Accelerator(TM)硬件与系统技术，其无需数百个计算节点就能够提供蛋白质识别处理能力。最近才推出的第二代Sorcerer 2 IDA是首款用于蛋白质处理的同类产品。它结合了供蛋白质组学研究人员使用的大型数据分析应用平台以及蛋白质识别加速算法，还内建了1.5TB的存储器用于储存分析结果。Sorcerer IDA是一款无与伦比的能够满足蛋白质组实验室众多用户的数据分析需要的设备，同时其还能够将所有分析结果进行归档。
了解关于Sorcerer IDA的更多信息，请访问网站http://www.SageNResearch.com/products/。
关于Sage-N Research, Inc.
Sage-N Research, Inc.是一家总部位于加利福尼亚州圣约瑟的在特拉华州注册的私人控股企业。Sage-N Research是开发包括Sequest Sorcerer蛋白质识别系统在内的易于使用的高处理能力综合数据设备的行业领导企业。公司已经以新型软件方法与硬件优化模式匹配算法为基础开发出专利技术。通过与领先科学家进行战略性合作，Sage-N Research推动设备、技术与易用性的提高，从而帮助完成能够改变世界的生物学与医药发现。了解更多信息，请访问公司网站 http://www.SageNResearch.com 。
关于Rosetta Elucidator系统
Rosetta Elucidator(R)蛋白质表达数据分析系统支持质谱蛋白质生物标志物发现，是一种面向蛋白质表达研究的全面解决方案。系统内置原始数据管理功能、用于定量与差量分析的LC/MS数据处理功能以及缩胺酸和蛋白水平上的蛋白质识别与高级分析功能。Elucidator系统拥有先进的数据管理功能，从而使得用户服务能够有效组织、查找与检索原始与加工过的蛋白质表达数据。设备能够用作蛋白质组研究的核心积分器，直接使用精心挑选出的工具APIs、示例注释系统与通用蛋白质标识搜索引擎。除此之外，系统还使得用户能够将蛋白质组数据与基因表达、代谢物、临床资料结合起来，从而发现生物标志物，并且在系统生物学层次上做出结论。Elucidator系统建立在Rosetta Biosoftware的稳定的信息学平台上，而信息学平台则结合了拥有高级搜索、分析、数据可视化与协同工具的关系型数据库。
了解关于Rosetta Elucidator系统的更多信息，请访问Rosetta Biosoftware网站 www.rosettabio.com 。
关于Rosetta Biosoftware：
Rosetta Biosoftware是面向生命科学研究的信息解决方案的主要供应商。它所开发的企业级软件解决方案包括Rosetta Resolver和Rosetta Elucidator系统，能够为生命科学家提供先进的、可伸缩的和易用的分析平台，从而推动发现研究工作的进展。Rosetta Biosoftware是默克公司(Merck & Co., Inc.)（纽约证券交易所：MRK）旗下企业Rosetta Inpharmatics LLC下属的业务单位。了解关于Rosetta Biosoftware的更多信息，请访问网站 www.rosettabio.com 。
前瞻性声明
根据《1995年私人证券改革法案》的规定的条款，本新闻稿中包含有“前瞻性声明”。这些前瞻性声明受到风险与不确定性的影响，可能会导致公司实际业绩与本声明中所表示之业绩存在重大差异。前瞻性声明包括与产品开发、产品潜力或者财务状况有关的声明。我们不会为前瞻性声明提供任何担保，实际业绩可能会与以上预测业绩存在重大差异。无论是由于新信息出现，未来事件发生或者其他任何原因，Rosetta Inpharmatics或者默克公司均不承担公开更新任何前瞻性声明的义务。读者在评估本新闻稿中的前瞻性声明时应该考虑到诸多会对默克公司业务产生影响的不确定性，这些不确定性包括但不仅限于Rosetta Inpharmatics的技术平台在多大程度上可以用于药品研发计划；Rosetta Inpharmatics技术的市场接受程度的不确定性；能否与现有技术进行竞争；以及默克公司在截止至2005年12月31日的10-K表格报告与10-Q表格和8-K表格定期报告（如果有的话）的第一项中的警告性声明提及的其他不确定性，上述声明仅供参考之用。
Rosetta Resolver和Elucidator是Rosetta Inpharmatics LLC在美国地区的注册商标。Sorcerer(TM)、Pattern Match Accelerator(TM)和Integrated Data Appliance Company(TM)是属于Sage-N Research, Inc所有的商标。
联系方式：Rosetta Biosoftware Lisa Owen，206-926-1236 网站：http://www.rosettabio.com/ 或者 Sage-N Research, Inc. David Chiang，408-350-0475 电子邮件：dchiang@SageNResearch.com 网站：http://www.SageNResearch.com/
(BW)(WA-ROSETTA-BIOSOFTWARE)(MRK) Rosetta Biosoftware and Sage-N Research, Inc. Collaborate on Informatics Environment for Proteomics and Biomarker Discovery
SEATTLE and SAN JOSE, Calif.--(BUSINESS WIRE)--April 19, 2006--
Rosetta Biosoftware and Sage-N Research, Inc. today announced a collaboration to establish interoperability between Rosetta Biosoftware’s Elucidator(R) system for protein expression analysis and biomarker discovery and Sage-N Research’s Sorcerer(TM) proteomic integrated data appliance to offer customers an advanced solution for protein expression research and protein identification.
The Rosetta Elucidator system is a flexible, scalable solution for managing and analyzing large volumes of proteomics data. It includes raw data management, the PeakTeller(TM) processing module to identify differentially-expressed proteins, and analysis at the peptide and protein level, enabling researchers to generate a list of candidate biomarkers from mass spectrometry data. The Sorcerer integrated data appliance from Sage-N Research is a compact analysis system that provides processing throughput for protein identification using patent-pending Pattern Match Accelerator(TM) hardware and systems technology.
"We are pleased to provide our mutual customers with automation and flexibility that will significantly increase productivity for protein biomarker discovery," said Yelena Shevelenko, vice president and general manager of Rosetta Biosoftware. "By combining the Elucidator system’s power to identify differentially-expressed proteins with the Sorcerer system’s high throughput, high resolution sequence searching capabilities, we are offering our customers increased throughput through automation and more time to focus on relevant scientific issues instead of validating protein search results."
"Sage-N Research and Rosetta Biosoftware share the vision of high-throughput, easy-to-use proteomic data analysis solutions," remarked David Chiang, C.E.O. and Chairman of Sage-N Research. "By combining the capabilities of these two products that are leaders in their own arenas, we offer the scientist a powerful and comprehensive environment for MS-MS based proteomic data analysis."
The benefits of the integration are immediately available to joint customers of the Sorcerer and Elucidator systems. Sage-N Research and Rosetta Biosoftware also intend to collaborate in supporting the combined solution for customers.
About the Sorcerer Integrated Data Appliance
The Sorcerer integrated data appliance (IDA) is a compact analysis system that sets up in minutes, and requires no software installation or IT administration. Using patent-pending Pattern Match Accelerator(TM) hardware and systems technology, it offers processing throughput for protein identification that otherwise might require hundreds of compute nodes. The recently introduced second generation Sorcerer 2 IDA is the first product of its kind for proteomics. It combines a platform for the major data analysis applications used by proteomics researchers together with accelerated algorithms for protein identification and a built-in 1.5 Terabyte repository for analysis results. The Sorcerer IDA is uniquely effective for serving the data analysis needs of multiple users of a proteomics laboratory and archiving all their results.
Additional information about the Sorcerer IDA can be found at http://www.SageNResearch.com/products/.
About Sage-N Research, Inc.
Sage-N Research, Inc. is a privately held corporation headquartered in San Jose, California and incorporated in the state of Delaware. Sage-N Research is an industry leader in developing high-throughput, easy-to-use integrated data appliances, including the Sequest Sorcerer protein identification system. The company has developed proprietary technology based on novel software methods and hardware-optimized pattern matching algorithms. Through strategic collaborations with leading scientists, Sage-N Research advances the state of the art in ease-of-use, applications, and technology to enable world-changing discoveries in biology and medicine. For more information, please visit http://www.SageNResearch.com.
About the Rosetta Elucidator System
The Rosetta Elucidator(R) Protein Expression Data Analysis system, with capabilities to support mass-spectrometry-based, protein biomarker discovery, is a complete solution for organizations involved in protein expression research. The system includes raw data management, LC/MS data processing for quantitative and differential analysis, protein identification and high-level analysis at the peptide and protein level. The Elucidator system’s advanced data management capabilities allow users to effectively organize, search for and retrieve raw and processed protein expression data. The application serves as a core integrator for proteomics research by working directly with select instrument APIs, sample annotation systems and common protein ID search engines. Additionally, the system enables users to integrate proteomics data with gene expression, metabolite, and clinical data to find biomarkers and make conclusions at the systems biology level. The Elucidator system is built on Rosetta Biosoftware’s stable informatics platform, which combines a powerful relational database with sophisticated search, analysis, data visualization, and collaboration tools.
Additional information about the Rosetta Elucidator system can be found on the Rosetta Biosoftware Web site at www.rosettabio.com.
About Rosetta Biosoftware:
Rosetta Biosoftware is a leading provider of informatics solutions for life science research. Its enterprise software solutions, including the Rosetta Resolver and Rosetta Elucidator systems, empower life scientists with advanced, scalable, and easy-to-use analysis platforms that accelerate discovery research. Rosetta Biosoftware is a business unit of Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc. (NYSE: MRK). More information about Rosetta Biosoftware is available at www.rosettabio.com.
Forward-Looking Statements
This press release contains "forward-looking statements" as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements may include statements regarding product development, product potential, or financial performance. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. Neither Rosetta Inpharmatics nor Merck & Co., Inc. undertakes any obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect the business of Merck & Co., Inc. including, among others, the extent to which Rosetta Inpharmatics’ technology platform can be used in drug discovery programs, uncertainty of market acceptance of Rosetta Inpharmatics’ technologies, ability to compete against existing technologies, and those mentioned in the cautionary statements in Item 1 of Merck’s Form 10-K for the year ended Dec. 31, 2005, and in its periodic reports on Form 10-Q and Form 8-K (if any) which are incorporated by reference.
Rosetta Resolver and Elucidator are U.S. registered trademarks of Rosetta Inpharmatics LLC. Sorcerer(TM), Pattern Match Accelerator(TM) and the Integrated Data Appliance Company(TM) are trademarks of Sage-N Research, Inc.
CONTACT: Rosetta Biosoftware Lisa Owen, 206-926-1236 website: http://www.rosettabio.com/ or Sage-N Research, Inc. David Chiang, 408-350-0475 email: dchiang@SageNResearch.com website: http://www.SageNResearch.com/
